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14 principal scientist jobs found in San Diego

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San Diego principal scientist
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Full time  (12)
Vertex
Sep 03, 2026
Optics / Microscopy Principal Scientist
Vertex San Diego, CA
Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has three approved medicines that treat the underlying cause of cystic fibrosis (CF) – a rare, life-threatening genetic disease — and has several ongoing clinical and research programs in CF. Beyond CF, Vertex has a robust pipeline of investigational medicines in other serious diseases where it has deep insight into causal human biology, such as sickle cell disease, beta thalassemia, pain, alpha-1 antitrypsin deficiency, Duchenne muscular dystrophy and APOL1-mediated kidney disease.
Novartis
Aug 26, 2026
Full time
Principal Scientist, Early Pipeline Development
Novartis San Diego, CA
At Novartis US, our mission is to reimagine medicine and discover new ways to improve and extend people's lives. As a leading global medicines company, we use innovative science and digital technologies to create transformative treatments in areas of great medical need. 
Novartis
Aug 26, 2026
Full time
Principal Scientist, Biophysicist
Novartis San Diego, CA
At Novartis US, our mission is to reimagine medicine and discover new ways to improve and extend people's lives. As a leading global medicines company, we use innovative science and digital technologies to create transformative treatments in areas of great medical need. 
Novartis
Aug 26, 2026
Full time
ADME Scientist, Antibody–Oligonucleotide Conjugates (Principal Scientist I/II)
Novartis San Diego, CA
At Novartis US, our mission is to reimagine medicine and discover new ways to improve and extend people's lives. As a leading global medicines company, we use innovative science and digital technologies to create transformative treatments in areas of great medical need. 
Novartis
Aug 26, 2026
Full time
Principal Scientist I/II – Hematopoietic Stem Cell & RBC Biology
Novartis San Diego, CA
At Novartis US, our mission is to reimagine medicine and discover new ways to improve and extend people's lives. As a leading global medicines company, we use innovative science and digital technologies to create transformative treatments in areas of great medical need. 
Novartis
Aug 26, 2026
Full time
Principal Scientist I/II – Hematopoietic Stem Cell & RBC Biology
Novartis San Diego, CA
At Novartis US, our mission is to reimagine medicine and discover new ways to improve and extend people's lives. As a leading global medicines company, we use innovative science and digital technologies to create transformative treatments in areas of great medical need. 
Merck
Aug 26, 2026
Full time
Associate Principal Scientist, Immunology Discovery
Merck San Diego, CA
At Merck, known as MSD outside of the United States and Canada, we are unified around our purpose: We use the power of leading-edge science to save and improve lives around the world. 
Johnson & Johnson Services, Inc
Aug 20, 2026
Full time
Principal Scientist, Data Science - Digital Media
Johnson & Johnson Services, Inc San Diego, CA
Johnson & Johnson is the world’s most broadly based healthcare organization and includes more than 275+ companies focused in medical devices, pharmaceuticals, and consumer products.
Johnson & Johnson Services, Inc
Aug 20, 2026
Full time
Senior Principal Scientist, Neuropsychiatry Discovery
Johnson & Johnson Services, Inc San Diego, CA
Johnson & Johnson is the world’s most broadly based healthcare organization and includes more than 275+ companies focused in medical devices, pharmaceuticals, and consumer products.
Genentech
Aug 18, 2026
Full time
Senior Principal Scientist: Metabolomics/Cell Therapy Media Development
Genentech San Diego, CA
Genentech, now a member of the Roche Group, is a leading biotechnology company that discovers, develops, manufactures and commercializes medicines to treat patients with serious or life-threatening medical conditions. 
Bristol Myers
Aug 13, 2026
Full time
Principal Scientist, Translational Computational Biology
Bristol Myers San Diego, CA
Bristol Myers Squibb is a global biopharmaceutical company committed to creating innovative medicines for millions of patients around the world fighting serious diseases in therapeutic areas such as oncology, hematology, immunology, cardiovascular and neuroscience. At the same time, we also nurture our own team with inspiring work and challenging career options.
Vertex
Sep 03, 2026
Medicinal Chemistry Senior Principal Research Scientist
Vertex San Diego, CA
Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has three approved medicines that treat the underlying cause of cystic fibrosis (CF) – a rare, life-threatening genetic disease — and has several ongoing clinical and research programs in CF. Beyond CF, Vertex has a robust pipeline of investigational medicines in other serious diseases where it has deep insight into causal human biology, such as sickle cell disease, beta thalassemia, pain, alpha-1 antitrypsin deficiency, Duchenne muscular dystrophy and APOL1-mediated kidney disease.
Johnson & Johnson Services, Inc
Aug 20, 2026
Full time
Principal Data Scientist - Oncology
Johnson & Johnson Services, Inc San Diego, CA
Johnson & Johnson is the world’s most broadly based healthcare organization and includes more than 275+ companies focused in medical devices, pharmaceuticals, and consumer products.
Johnson & Johnson Services, Inc
Aug 20, 2026
Full time
Principal Data Scientist - Immunology - (2 positions)
Johnson & Johnson Services, Inc San Diego, CA
Johnson & Johnson is the world’s most broadly based healthcare organization and includes more than 275+ companies focused in medical devices, pharmaceuticals, and consumer products.
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