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16 principal scientist jobs found in Boston

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Boston principal scientist
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Full time  (9)
Vertex
Sep 03, 2026
Analytical Development Principal Scientist
Vertex Boston, MA
Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has three approved medicines that treat the underlying cause of cystic fibrosis (CF) – a rare, life-threatening genetic disease — and has several ongoing clinical and research programs in CF. Beyond CF, Vertex has a robust pipeline of investigational medicines in other serious diseases where it has deep insight into causal human biology, such as sickle cell disease, beta thalassemia, pain, alpha-1 antitrypsin deficiency, Duchenne muscular dystrophy and APOL1-mediated kidney disease.
Vertex
Sep 03, 2026
Senior Principal Scientist, Applied AI & Agentic Systems for Small-Molecule Drug Discovery
Vertex Boston, MA
Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has three approved medicines that treat the underlying cause of cystic fibrosis (CF) – a rare, life-threatening genetic disease — and has several ongoing clinical and research programs in CF. Beyond CF, Vertex has a robust pipeline of investigational medicines in other serious diseases where it has deep insight into causal human biology, such as sickle cell disease, beta thalassemia, pain, alpha-1 antitrypsin deficiency, Duchenne muscular dystrophy and APOL1-mediated kidney disease.
Vertex
Sep 03, 2026
Senior Principal Scientist, Agentic Systems Development for Drug Discovery
Vertex Boston, MA
Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has three approved medicines that treat the underlying cause of cystic fibrosis (CF) – a rare, life-threatening genetic disease — and has several ongoing clinical and research programs in CF. Beyond CF, Vertex has a robust pipeline of investigational medicines in other serious diseases where it has deep insight into causal human biology, such as sickle cell disease, beta thalassemia, pain, alpha-1 antitrypsin deficiency, Duchenne muscular dystrophy and APOL1-mediated kidney disease.
Vertex
Sep 03, 2026
Principal Scientist, Separation Methods Expert, Analytical Science and Technology (AS&T), Vertex Pharmaceuticals (Boston)
Vertex Boston, MA
Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has three approved medicines that treat the underlying cause of cystic fibrosis (CF) – a rare, life-threatening genetic disease — and has several ongoing clinical and research programs in CF. Beyond CF, Vertex has a robust pipeline of investigational medicines in other serious diseases where it has deep insight into causal human biology, such as sickle cell disease, beta thalassemia, pain, alpha-1 antitrypsin deficiency, Duchenne muscular dystrophy and APOL1-mediated kidney disease.
Vertex
Sep 03, 2026
Aseptic Control Principal Scientist, MSAT
Vertex Boston, MA
Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has three approved medicines that treat the underlying cause of cystic fibrosis (CF) – a rare, life-threatening genetic disease — and has several ongoing clinical and research programs in CF. Beyond CF, Vertex has a robust pipeline of investigational medicines in other serious diseases where it has deep insight into causal human biology, such as sickle cell disease, beta thalassemia, pain, alpha-1 antitrypsin deficiency, Duchenne muscular dystrophy and APOL1-mediated kidney disease.
Merck
Aug 26, 2026
Full time
Associate Principal Scientist, In Vivo Pharmacology, Oncology
Merck Boston, MA
At Merck, known as MSD outside of the United States and Canada, we are unified around our purpose: We use the power of leading-edge science to save and improve lives around the world. 
Merck
Aug 26, 2026
Full time
Principal Scientist, DMPK
Merck Boston, MA
At Merck, known as MSD outside of the United States and Canada, we are unified around our purpose: We use the power of leading-edge science to save and improve lives around the world. 
Merck
Aug 26, 2026
Full time
Principal Scientist, Early Clinical Development, Respiratory Therapeutic Area
Merck Boston, MA
At Merck, known as MSD outside of the United States and Canada, we are unified around our purpose: We use the power of leading-edge science to save and improve lives around the world. 
Merck
Aug 26, 2026
Full time
Associate Principal Scientist, Health Economic and Decision Sciences
Merck Boston, MA
At Merck, known as MSD outside of the United States and Canada, we are unified around our purpose: We use the power of leading-edge science to save and improve lives around the world. 
Merck
Aug 26, 2026
Full time
Sr. Principal Scientist (Sr. Director) - Regulatory Liaison
Merck Boston, MA
At Merck, known as MSD outside of the United States and Canada, we are unified around our purpose: We use the power of leading-edge science to save and improve lives around the world. 
Merck
Aug 26, 2026
Full time
Associate Principal Scientist, Clinical Research
Merck Boston, MA
At Merck, known as MSD outside of the United States and Canada, we are unified around our purpose: We use the power of leading-edge science to save and improve lives around the world. 
Bayer
Aug 12, 2026
Full time
Principal Scientist, Computational Designer (Biologics & Peptides)
Bayer Boston, MA
At Bayer, our largest segment in terms of sales, we focus on researching, developing and marketing specialty-focused innovative medicines that provide significant clinical benefit and value, primarily in the therapeutic areas of cardiology, oncology, gynecology, hematology and ophthalmology. In this way, we are addressing the growing requirements of patients, physicians, health care payers and regulatory agencies.
Vertex
Sep 03, 2026
Computational Chemistry Principal Research Scientist (Computational Drug Design)
Vertex Boston, MA
Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has three approved medicines that treat the underlying cause of cystic fibrosis (CF) – a rare, life-threatening genetic disease — and has several ongoing clinical and research programs in CF. Beyond CF, Vertex has a robust pipeline of investigational medicines in other serious diseases where it has deep insight into causal human biology, such as sickle cell disease, beta thalassemia, pain, alpha-1 antitrypsin deficiency, Duchenne muscular dystrophy and APOL1-mediated kidney disease.
Vertex
Sep 03, 2026
Analytical Principal Research Scientist
Vertex Boston, MA
Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has three approved medicines that treat the underlying cause of cystic fibrosis (CF) – a rare, life-threatening genetic disease — and has several ongoing clinical and research programs in CF. Beyond CF, Vertex has a robust pipeline of investigational medicines in other serious diseases where it has deep insight into causal human biology, such as sickle cell disease, beta thalassemia, pain, alpha-1 antitrypsin deficiency, Duchenne muscular dystrophy and APOL1-mediated kidney disease.
Genentech
Aug 18, 2026
Full time
Principal Data Scientist (AI-assisted Clinical Development)
Genentech Boston, MA
Genentech, now a member of the Roche Group, is a leading biotechnology company that discovers, develops, manufactures and commercializes medicines to treat patients with serious or life-threatening medical conditions. 
AstraZeneca
Jun 15, 2026
Full time
Associate Principal AI Research Scientist (Fundamental AI Research for Digital Biology)
AstraZeneca Boston, MA
At AstraZeneca our mission is to create an inclusive and equitable environment, where people feel they belong. Our ongoing commitment to inclusion and diversity means we’re future proofing our business. It allows us to push the boundaries of science and deliver life-changing medicines to more and more patients around the world.
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