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142 principal engineer jobs found

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Vertex
Sep 03, 2026
Principal Engineer, VaiDA Mobile Experience
Vertex Boston, MA
Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has three approved medicines that treat the underlying cause of cystic fibrosis (CF) – a rare, life-threatening genetic disease — and has several ongoing clinical and research programs in CF. Beyond CF, Vertex has a robust pipeline of investigational medicines in other serious diseases where it has deep insight into causal human biology, such as sickle cell disease, beta thalassemia, pain, alpha-1 antitrypsin deficiency, Duchenne muscular dystrophy and APOL1-mediated kidney disease.
Vertex
Sep 03, 2026
Principal Engineer, VaiDA User Experience
Vertex Boston, MA
Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has three approved medicines that treat the underlying cause of cystic fibrosis (CF) – a rare, life-threatening genetic disease — and has several ongoing clinical and research programs in CF. Beyond CF, Vertex has a robust pipeline of investigational medicines in other serious diseases where it has deep insight into causal human biology, such as sickle cell disease, beta thalassemia, pain, alpha-1 antitrypsin deficiency, Duchenne muscular dystrophy and APOL1-mediated kidney disease.
Vertex
Sep 03, 2026
Cybersecurity Principal Engineer (Palo Alto) - HYBRID ROLE
Vertex Boston, MA
Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has three approved medicines that treat the underlying cause of cystic fibrosis (CF) – a rare, life-threatening genetic disease — and has several ongoing clinical and research programs in CF. Beyond CF, Vertex has a robust pipeline of investigational medicines in other serious diseases where it has deep insight into causal human biology, such as sickle cell disease, beta thalassemia, pain, alpha-1 antitrypsin deficiency, Duchenne muscular dystrophy and APOL1-mediated kidney disease.
Novartis
Aug 26, 2026
Full time
Principal Engineer, MS&T
Novartis Durham, NC
At Novartis US, our mission is to reimagine medicine and discover new ways to improve and extend people's lives. As a leading global medicines company, we use innovative science and digital technologies to create transformative treatments in areas of great medical need. 
Lilly Pharmaceuticals
Aug 21, 2026
Full time
Principal - Engineer – Automation (Building Management Systems)
Lilly Pharmaceuticals Houston, TX
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. 
Lilly Pharmaceuticals
Aug 21, 2026
Full time
Principal - Engineer - Automation (Data & Platforms integration)
Lilly Pharmaceuticals Houston, TX
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. 
Lilly Pharmaceuticals
Aug 21, 2026
Full time
Sr Principal Engineer - MES Systems
Lilly Pharmaceuticals Richmond, VA
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. 
Lilly Pharmaceuticals
Aug 21, 2026
Full time
Sr. Principal - Engineer - Automation (Small Molecule)
Lilly Pharmaceuticals Houston, TX
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. 
Lilly Pharmaceuticals
Aug 21, 2026
Full time
Principal - Engineer - Automation (DeltaV System Administrator)
Lilly Pharmaceuticals Houston, TX
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. 
Lilly Pharmaceuticals
Aug 21, 2026
Full time
Principal Engineer – Visual Inspection
Lilly Pharmaceuticals Pleasant Prairie, WI
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. 
Lilly Pharmaceuticals
Aug 21, 2026
Full time
Sr Principal Engineer - HSE Global Facilities Delivery
Lilly Pharmaceuticals Huntsville, AL
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. 
Lilly Pharmaceuticals
Aug 21, 2026
Full time
Sr Principal Engineer - HSE Global Facilities Delivery
Lilly Pharmaceuticals Allentown, PA
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. 
Lilly Pharmaceuticals
Aug 21, 2026
Full time
Sr Principal Engineer - HSE Global Facilities Delivery
Lilly Pharmaceuticals Houston, TX
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. 
Lilly Pharmaceuticals
Aug 21, 2026
Full time
Principal Engineer - Robotics (R3-R4)
Lilly Pharmaceuticals Indianapolis, IN
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. 
Lilly Pharmaceuticals
Aug 21, 2026
Full time
Senior Principal Engineer (R4-R6)
Lilly Pharmaceuticals Concord, NC
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. 
Lilly Pharmaceuticals
Aug 21, 2026
Full time
Sr Principal Engineer - HSE Global Facilities Delivery
Lilly Pharmaceuticals Richmond, VA
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. 
Lilly Pharmaceuticals
Aug 21, 2026
Full time
Sr Principal Engineer - HSE Global Facilities Delivery
Lilly Pharmaceuticals Indianapolis, IN
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. 
Lilly Pharmaceuticals
Aug 21, 2026
Full time
Senior Principal Engineer - Automation Engineering – Hybrid Manufacturing - Lilly Medicine Foundry
Lilly Pharmaceuticals Lebanon, IN
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. 
Lilly Pharmaceuticals
Aug 21, 2026
Full time
Senior Principal Engineer - Automation Engineering – Hybrid Manufacturing - Lilly Medicine Foundry
Lilly Pharmaceuticals Indianapolis, IN
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. 
Lilly Pharmaceuticals
Aug 21, 2026
Full time
Sr. Principal Engineer, Automation Engineering, Controls System Hardware - Lilly Medicine Foundry
Lilly Pharmaceuticals Lebanon, IN
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. 
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