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9 principal research scientist jobs found

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Vertex
Sep 03, 2026
Computational Chemistry Principal Research Scientist (Computational Drug Design)
Vertex Boston, MA
Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has three approved medicines that treat the underlying cause of cystic fibrosis (CF) – a rare, life-threatening genetic disease — and has several ongoing clinical and research programs in CF. Beyond CF, Vertex has a robust pipeline of investigational medicines in other serious diseases where it has deep insight into causal human biology, such as sickle cell disease, beta thalassemia, pain, alpha-1 antitrypsin deficiency, Duchenne muscular dystrophy and APOL1-mediated kidney disease.
Vertex
Sep 03, 2026
Analytical Principal Research Scientist
Vertex Boston, MA
Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has three approved medicines that treat the underlying cause of cystic fibrosis (CF) – a rare, life-threatening genetic disease — and has several ongoing clinical and research programs in CF. Beyond CF, Vertex has a robust pipeline of investigational medicines in other serious diseases where it has deep insight into causal human biology, such as sickle cell disease, beta thalassemia, pain, alpha-1 antitrypsin deficiency, Duchenne muscular dystrophy and APOL1-mediated kidney disease.
Vertex
Sep 03, 2026
Discovery Immunology Principal Research Scientist
Vertex Seattle, WA
Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has three approved medicines that treat the underlying cause of cystic fibrosis (CF) – a rare, life-threatening genetic disease — and has several ongoing clinical and research programs in CF. Beyond CF, Vertex has a robust pipeline of investigational medicines in other serious diseases where it has deep insight into causal human biology, such as sickle cell disease, beta thalassemia, pain, alpha-1 antitrypsin deficiency, Duchenne muscular dystrophy and APOL1-mediated kidney disease.
Vertex
Sep 03, 2026
Medicinal Chemistry Senior Principal Research Scientist
Vertex San Diego, CA
Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has three approved medicines that treat the underlying cause of cystic fibrosis (CF) – a rare, life-threatening genetic disease — and has several ongoing clinical and research programs in CF. Beyond CF, Vertex has a robust pipeline of investigational medicines in other serious diseases where it has deep insight into causal human biology, such as sickle cell disease, beta thalassemia, pain, alpha-1 antitrypsin deficiency, Duchenne muscular dystrophy and APOL1-mediated kidney disease.
Novartis
Aug 26, 2026
Full time
Senior Principal Scientist / Assoc Director, Oncology Translational Research
Novartis Cambridge, MA
At Novartis US, our mission is to reimagine medicine and discover new ways to improve and extend people's lives. As a leading global medicines company, we use innovative science and digital technologies to create transformative treatments in areas of great medical need. 
Bristol Myers
Aug 13, 2026
Full time
Principal Scientist, ADCs Discovery Biology, Oncology Thematic Research Center
Bristol Myers Cambridge, MA
Bristol Myers Squibb is a global biopharmaceutical company committed to creating innovative medicines for millions of patients around the world fighting serious diseases in therapeutic areas such as oncology, hematology, immunology, cardiovascular and neuroscience. At the same time, we also nurture our own team with inspiring work and challenging career options.
Bristol Myers
Aug 13, 2026
Full time
Senior Principal Scientist, Cancer Immunology, Discovery Biology, Oncology Thematic Research Center
Bristol Myers Seattle, WA
Bristol Myers Squibb is a global biopharmaceutical company committed to creating innovative medicines for millions of patients around the world fighting serious diseases in therapeutic areas such as oncology, hematology, immunology, cardiovascular and neuroscience. At the same time, we also nurture our own team with inspiring work and challenging career options.
Bristol Myers
Aug 13, 2026
Full time
Principal Scientist - Cell Therapy Translational Research
Bristol Myers Seattle, WA
Bristol Myers Squibb is a global biopharmaceutical company committed to creating innovative medicines for millions of patients around the world fighting serious diseases in therapeutic areas such as oncology, hematology, immunology, cardiovascular and neuroscience. At the same time, we also nurture our own team with inspiring work and challenging career options.
Astellas
Aug 11, 2026
Full time
Principal Scientist, Ophthalmology Research
Astellas Westborough, MA
Developing innovative therapies is one of the most challenging, most essential and personally rewarding fields in science. Everything we do is led by our company values of integrity, being patient centric, taking ownership, delivering results and communicating openly. These values are essential to Astellas’ relationship with its employees. Our people humanize us, grow us, are the heart of everything we create and do with integrity. So bring your unique experience, perspective, thinking and ideas.
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